Neuroprotective Supplements for ALS Management
Understanding the potential mechanisms and effects of key compounds.
Vitamin E, B-Vitamins, & Zinc
Creatine & Amino Acids
Herbs & Botanicals
Neuroprotective Compounds
| Compound | Mechanisms of Action | Neuroprotective Effects |
|---|---|---|
| Vitamin E | Antioxidant, anti-inflammatory, membrane stabilization | Protects white matter, reduces neuroinflammation, supports synaptic integrity |
| B Vitamins (Folic Acid, B6, B12) | Homocysteine regulation, neurotransmitter synthesis, myelin maintenance | Enhances nerve regeneration, reduces cognitive decline, supports neural connectivity |
| Zinc | Antioxidant, synaptic modulation, gene expression regulation | Supports neurogenesis, protects against oxidative stress, imbalance can be neurotoxic |
| Genistein | Antioxidant, anti-inflammatory, Nrf2 and PI3K/Akt pathway modulation | Prevents amyloid-beta accumulation, improves memory, protects mitochondria |
| Melatonin | Antioxidant, circadian rhythm regulation, mitochondrial protection | Reduces neuroinflammation, protects against ischemia, supports cognitive resilience |
| Creatine | ATP buffering, mitochondrial support, anti-inflammatory | Enhances cognition under stress, supports brain energy metabolism |
| Coenzyme Q10 | Mitochondrial electron transport, antioxidant, anti-apoptotic | Protects neurons in Parkinson's, Alzheimer's, supports mitochondrial health |
| Alpha-lipoic Acid | Antioxidant, mitochondrial function enhancement, anti-inflammatory | Improves memory, reduces oxidative damage, slows neurodegeneration |
| L-Carnitine (Acetyl-L-Carnitine) | Fatty acid transport into mitochondria, neurotransmitter modulation | Enhances mental energy, supports memory and mood |
| Glutathione, NAC, Pro-cysteine | Glutathione synthesis, detoxification, redox regulation | Protects against oxidative stress, supports cognition, helps in neurodegenerative diseases |
| Herbs & L-Carnosine | Antioxidant, anti-inflammatory, neurotrophic (varies by herb) | Reduces glycation, oxidative damage; herbs like Bacopa and Ginkgo improve cognition |
© 2025
All Rights Reserved.